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Mass Spectrometry Laboratory

Adriana Paes Leme

adriana.paesleme@lnbio.cnpem.br

Brazilian Biosciences National Laboratory

National Center for Research in Energy and Materials - CNPEM

lnbio.cnpem.br/facilities/mass-spectrometry

EVs research

EVs as diagnostic tools.

Recent publications

1- Busso-Lopes AF, Carnielli CM, Winck FV, Patroni FMS, Oliveira AK, Granato DC, E Costa RAP, Domingues RR, Pauletti BA, Riaño-Pachón DM, Aricetti J, Caldana C, Graner E, Coletta RD, Dryden K, Fox JW, Paes Leme AF. A Reductionist Approach Using Primary and Metastatic Cell-Derived Extracellular Vesicles Reveals Hub Proteins Associated with Oral Cancer Prognosis. Mol Cell Proteomics. 2021 Jun 27;20:100118. doi: 10.1016/j.mcpro.2021.100118. Epub ahead of print. PMID: 34186243; PMCID: PMC8350068.

2- Lobastova L, Lettau M, Babatz F, de Oliveira TD, Nguyen PH, Pauletti BA, Schauss AC, Dürkop H, Janssen O, Paes Leme AF, Hallek M, Hansen HP. CD30-Positive Extracellular Vesicles Enable the Targeting of CD30-Negative DLBCL Cells by the CD30 Antibody-Drug Conjugate Brentuximab Vedotin. Front Cell Dev Biol. 2021 Jul 30;9:698503. doi: 10.3389/fcell.2021.698503. PMID: 34395429; PMCID: PMC8362802.

3- Sá JO, Trino LD, Oliveira AK, Lopes AFB, Granato DC, Normando AGC, Santos ES, Neves LX, Carnielli CM, Paes Leme AF. Proteomic approaches to assist in diagnosis and prognosis of oral cancer. Expert Rev Proteomics. 2021 Apr;18(4):261-284. doi: 10.1080/14789450.2021.1924685. Epub 2021 May 18. PMID: 33945368.

4- Neves LX, Granato DC, Busso-Lopes AF, Carnielli CM, Patroni FMS, De Rossi T, Oliveira AK, Ribeiro ACP, Brandão TB, Rodrigues AN, Lacerda PA, Uno M, Cervigne NK, Santos-Silva AR, Kowalski LP, Lopes MA, Paes Leme AF. Peptidomics-Driven Strategy Reveals Peptides and Predicted Proteases Associated With Oral Cancer Prognosis. Mol Cell Proteomics. 2020 Dec 3;20:100004. doi: 10.1074/mcp.RA120.002227. Epub ahead of print. PMID: 33578082; PMCID: PMC7950089.

5- Ribeiro-Filho HV, Coimbra LD, Cassago A, Rocha RPF, Guerra JVDS, de Felicio R, Carnieli CM, Leme L, Padilha AC, Paes Leme AF, Trivella DBB, Portugal RV, Lopes-de-Oliveira PS, Marques RE. Cryo-EM structure of the mature and infective Mayaro virus at 4.4 Å resolution reveals features of arthritogenic alphaviruses. Nat Commun. 2021 May 24;12(1):3038. doi: 10.1038/s41467-021-23400-9. PMID: 34031424; PMCID: PMC8144435.