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Laboratory of gene expression regulation

Marcio Rodrigues

marcio.rodrigues@fiocruz.br

Carlos Chagas Institute

Fiocruz

EVs research

EVs in host and infectious agents (viruses, parasites, fungi, and bacteria).

Recent publications

1- Reis FCG, Gimenez B, Jozefowicz LJ, Castelli RF, Martins ST, Alves LR, de Oliveira HC, Rodrigues ML. Analysis of Cryptococcal Extracellular Vesicles: Experimental Approaches for Studying Their Diversity Among Multiple Isolates, Kinetics of Production, Methods of Separation, and Detection in Cultures of Titan Cells. Microbiol Spectr. 2021 Sep 3;9(1):e0012521. doi: 10.1128/Spectrum.00125-21.

2- Rodrigues ML. The Benefits of Exporting: Engineered Extracellular Vesicles as Promising Vaccine Candidates against Enteric Fever. Infect Immun. 2021 Mar 17;89(4):e00001-21. doi: 10.1128/IAI.00001-21.

3- Reis FCG, Costa JH, Honorato L, Nimrichter L, Fill TP, Rodrigues ML. Small Molecule Analysis of Extracellular Vesicles Produced by Cryptococcus gattii: Identification of a Tripeptide Controlling Cryptococcal Infection in an Invertebrate Host Model. Front Immunol. 2021 Mar 16;12:654574. doi: 10.3389/fimmu.2021.654574.

4- Costa JH, Bazioli JM, Barbosa LD, Dos Santos Júnior PLT, Reis FCG, Klimeck T, Crnkovic CM, Berlinck RGS, Sussulini A, Rodrigues ML, Fill TP. Phytotoxic Tryptoquialanines Produced In Vivo by Penicillium digitatum Are Exported in Extracellular Vesicles. mBio. 2021 Feb 9;12(1):e03393-20. doi: 10.1128/mBio.03393-20.

5- Rizzo J, Chaze T, Miranda K, Roberson RW, Gorgette O, Nimrichter L, Matondo M, Latgé JP, Beauvais A, Rodrigues ML. Characterization of Extracellular Vesicles Produced by Aspergillus fumigatus Protoplasts. mSphere. 2020 Aug 12;5(4):e00476-20. doi: 10.1128/mSphere.00476-20. PMID: 32817450; PMCID: PMC7426166.